Asymmetric catalysis with N-heterocyclic carbenes as non-covalent chiral templates
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چکیده
منابع مشابه
Asymmetric catalysis with N-heterocyclic carbenes as non-covalent chiral templates.
N-heterocyclic carbenes are a class of persistent carbenes stabilized by adjacent heteroatoms that are part of a heterocycle. They play a central role in multiple enzymatic biosynthetic reactions that involve thiamine diphosphate. Inspired by this biocatalysis machinery, N-heterocyclic carbenes have emerged as one of the most versatile classes of organocatalysts for organic reactions. However, ...
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C(1)-symmetric isoquinoline-based chiral diaminocarbene ligands (MIQ) have been developed to block three quadrants of the metal coordination sphere, complementing C(2)-symmetric biisoquinoline-based ligands (BIQ). MIQ-Cu complexes catalyzed conjugate borylation of various α,β-unsaturated amides in good yields (82-99%) and enantioselectivities (75-87% ee).
متن کاملN-Heterocyclic carbenes
The N-heterocyclic carbenes (NHC) now hold a preferredligand status in organic and organometallic chemistry. Their role in catalysis continues to grow. When the editorial staff at the Beilstein Journal of Organic Chemistry contacted me to act as a guest editor for the thematic series “N-Heterocyclic carbenes”, I was more than happy to accept what appeared to me to be a simple and exciting endea...
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Seven coinage metal(I) complexes bearing two different triazole-based N-heterocyclic carbene (NHC) ligands, [1-tert-butyl-4-{2-[(N,N-dimethylamino)methyl]phenyl}-3-phenyl-1H-1,2,4-triazol-4-ium-5-ide and 1-tert-butyl-4-(4-methylphenyl)-3-phenyl-1H-1,2,4-triazol-4-ium-5-ide], were synthesized and fully characterized in solution by NMR spectroscopy as well as in the solid state by X-ray diffracti...
متن کاملExpanded ring and functionalised expanded ring N-heterocyclic carbenes as ligands in catalysis.
The synthesis of new functionalised 6- and 7-membered NHC (N-heterocyclic carbene) precursors bearing anisidyl or pyridine N-substituents, both symmetrically and non-symmetrically substituted is reported. Their corresponding rhodium(i) and iridium(i) complexes, M(COD)(NHC)Cl, were also prepared and characterised. The unusual Rh(iii)/Rh(i) salt, [Rh(eta(2)-NHC-py)(2)Cl(2)][Rh(COD)Cl(2)], was obt...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2014
ISSN: 2041-1723
DOI: 10.1038/ncomms4437